I agree that showing a young inexperienced QB on their side some of our looks with Base 3LB defense could pay benefits in s few areas:
Bigger personnel on Bills at second level to fill gaps and shut down 49ers Run game. 49ers like to do stretch plays to perimeter and Milano and Edmunds offer great options to shut this down via outstanding pursuit ability.
Playing Klein in a Zo like SAM role allows him to push upfield on Strong Side and disrupt the blocking scheme and force play back inside on sweeps and outside zone runs.
Milano, Edmunds and Klein can stay on field and cover RB/FB and 2TEs in the 49ers 22 sets and even their 12 sets.
DL should focus on hands up as Mullins (who is only 6'1") likes quick release, under or slant patterns. Pass knockdowns or - better yet, tipped passes - will help limit the 49ers success on early downs. Our LBs and Safeties should also have some good chances at some INTs tomorrow.
Klein and Milano can blitz from their SAM or WIL positions and get to Mullins on passing downs more frequently than a CB or Safety.
Here's hoping Milano is a go and Leslie Frazier and McDermott scheme up some new wrinkles!