If it weren't a division game, I'd say it's kind of a throw away game since it's week one. The interviews since the end of last year have been about getting hot at the end of the year and using the beginning of the year as a tune up.
With the Bills schedule, I don't know if they can afford to do it this year. The last 8 games are a gauntlet, as it looks right now. Last year they came out smoking hot and fizzled at the end.