Know anyone with a disease? Read this

[John Adams]

Who cares? Is there someone here arguing against medical pot? Anyone?

 

But let me repeat my question: Is the goal of the medical pot movement medicine or free pot for everyone?

 

Answer honestly. We all know it's a ruse for the stoners to get easier weed access. Do you admit it or will you keep up with the "medical" propaganda?

Edited July 20, 2014 by John Adams

[Bob in Mich]

Yes, there are several people here arguing against it.

 

The truth is that there is not any strongly organized medical pot movement, at least that I know of. There are some organizations but they are weak and poorly funded. State by state, laws have been changed and seemingly citizens start anew battling the same issues over again that were battled in the last state. There is little carryover from other states.

 

Money drives politics these days and most patients are sick or disabled and that equates to poor. Had cannabis had the power of the drug lobby behind it, we would all be smelling skunky these days.

 

Within the last year or so, Wall Street has been taking notice of the potential and so the latest drivers in the cannabis arena are business and profit potential. Business can often blur the medical/recreational line as so many businesses do not care. This will move the country toward legalization much faster than any compassion for the sick.

[FireChan]

Yes, there are several people here arguing against it.

 

The truth is that there is not any strongly organized medical pot movement, at least that I know of. There are some organizations but they are weak and poorly funded. State by state, laws have been changed and seemingly citizens start anew battling the same issues over again that were battled in the last state. There is little carryover from other states.

 

Money drives politics these days and most patients are sick or disabled and that equates to poor. Had cannabis had the power of the drug lobby behind it, we would all be smelling skunky these days.

 

Within the last year or so, Wall Street has been taking notice of the potential and so the latest drivers in the cannabis arena are business and profit potential. Business can often blur the medical/recreational line as so many businesses do not care. This will move the country toward legalization much faster than any compassion for the sick.

 

Yes, there are several people here arguing against it.

 

Who? I've been arguing against your BS claims, not the legalization of medical marijuana.

 

Wall Street has been taking notice of the potential and so the latest drivers in the cannabis arena are business and profit potential. Business can often blur the medical/recreational line as so many businesses do not care. This will move the country toward legalization much faster than any compassion for the sick.

 

Can you explain to me what this means? What potential does Wall Street see? What Wall Street groups are backing state legalization laws? Since when is cannabis the only medicine driven by profit? How does business blur the lines between medical and recreational use? What do they not care about, who uses it or if it works? Compassion won't move the country towards legalization for recreational use or medical use?

 

Would you be okay with marijuana being completely legal with a prescription, but completely illegal without one?

[John Adams]

Who is arguing against legalization on this board?

[Bob in Mich]

Tell ya what Chano, take a deep breath and consider if you actually want anything answered or you just want to agitate. At the moment I question your sincerity.

 

I'll start ya off on the business angle of cannabis growth and you can research from here or not.

 

Exponential sales growth is forecast in industries that supply cannabis, process cannabis, vaporize cannabis, and a hundred different ancillary businesses that can grow up around this industry. Everyone and their brother is starting cannabis related companies and investors flocked to put money into them. They have spiked and fallen and spiked and fallen a few times. It is a pending green rush that is just waiting on the the right time.

 

It is a sector that is driven by news and makes huge moves when it moves. Here are some of the companies in the sector. http://www.marijuanaindex.org/

 

"daily marijuana smoking is a risk factor for progression of fibrosis among people with chronic hepatitis C infection"

 

Someone with Hep C? Marijuana can cure that **** probably! Heart condition? Oh, don't bother telling your doctor you're using marijuana behind his back, you'll be cured in no time!

 

The wonder drug, coming with horrific side-effects to a pharmacy near you! Just make sure you don't tell your doctor about it!

 

Oh, I almost forgot. Here is a more recent study on cannabis and liver function. Check it out.

 

Marijuana smoking does not appear to cause progression of liver fibrosis in the Canadian HIV/HCV Co-infection Cohort study

April 2012

 

Authors:Brunet L, Moodie EE, Rollet K, Tyndall M, Potter M, Conway B, Walmsley S, Pick N, Cooper C, Cox J, Klein MB for the Canadian Co-infection Cohort (CTN222)

 

Location: 21st Annual Canadian Conference on HIV/AIDS Research (CAHR 2012) Montreal

 

Background:

The literature on the effect of cannabis

on liver diseases is conflicting. Cell cultures and animal model studies

conclude that cannabidiol could have a therapeutic effect on liver

injuries. However, cross-sectional studies of chronic HCV

patients suggest that daily cannabis use is associated with fibrosis

and steatosis. This study aims at estimating the causal effect of

marijuana use on liver fibrosis progression in the Canadian Co-infection Cohort study.

 

Conclusion:

Marijuana smoking does not have a causal effect on

progression to liver disease in co-infected individuals.

 

http://www.ncbi.nlm....les/PMC3739469/

Edited July 21, 2014 by Bob in Mich

[FireChan]

Tell ya what Chano, take a deep breath and consider if you actually want anything answered or you just want to agitate. At the moment I question your sincerity.

 

I'll start ya off on the business angle of cannabis growth and you can research from here or not.

 

Exponential sales growth is forecast in industries that supply cannabis, process cannabis, vaporize cannabis, and a hundred different ancillary businesses that can grow up around this industry. Everyone and their brother is starting cannabis related companies and investors flocked to put money into them. They have spiked and fallen and spiked and fallen a few times. It is a pending green rush that is just waiting on the the right time.

 

It is a sector that is driven by news and makes huge moves when it moves. Here are some of the companies in the sector. http://www.marijuanaindex.org/

 

 

 

Oh, I almost forgot. Here is a more recent study on cannabis and liver function. Check it out.

 

Marijuana smoking does not appear to cause progression of liver fibrosis in the Canadian HIV/HCV Co-infection Cohort study

April 2012

 

Authors:Brunet L, Moodie EE, Rollet K, Tyndall M, Potter M, Conway B, Walmsley S, Pick N, Cooper C, Cox J, Klein MB for the Canadian Co-infection Cohort (CTN222)

 

Location: 21st Annual Canadian Conference on HIV/AIDS Research (CAHR 2012) Montreal

 

Background:

The literature on the effect of cannabis

on liver diseases is conflicting. Cell cultures and animal model studies

conclude that cannabidiol could have a therapeutic effect on liver

injuries. However, cross-sectional studies of chronic HCV

patients suggest that daily cannabis use is associated with fibrosis

and steatosis. This study aims at estimating the causal effect of

marijuana use on liver fibrosis progression in the Canadian Co-infection Cohort study.

 

Conclusion:

Marijuana smoking does not have a causal effect on

progression to liver disease in co-infected individuals.

 

http://www.ncbi.nlm....les/PMC3739469/

 

Are you a scientist?

 

Because, if you were, one study with a this, "Although the relatively short follow-up time and the lack of information on duration of smoking before cohort entry do not allow us to make inference about long-term use of marijuana," as a disclaimer, wouldn't have been used to proved your point.

 

If you haven't reached my point yet, (even though I've been making it all along), I don't believe medical marijuana is as miraculous as you say. You claim it might cure numerous diseases, but I haven't seen the data for that. You say it doesn't have side-effects like vicodin, but I'm sure that will change as well. With your promotion of hiding your drug use from your doctor, I'm inclined to believe you are not a health-care professional. And that everything you say needs to be taken with a grain of salt.

Edited July 21, 2014 by FireChan

[Bob in Mich]

Chano, I never claimed to be a health care professional.

 

I no longer care what you believe. It is clear to me that it is not worth the effort that I have put into trying to help you. You have been wasting my time

 

Still unconvinced? I'm OK with that outcome.

[FireChan]

Chano, I never claimed to be a health care professional.

 

I no longer care what you believe. It is clear to me that it is not worth the effort that I have put into trying to help you. You have been wasting my time

 

Still unconvinced? I'm OK with that outcome.

 

Help me how? By telling me things that are incorrect or unproven to "open my mind to medical marijuana?"

 

I'm doing a public service to ensure no one thinks you're an authority on this.

[Bob in Mich]

Some more good news. Illinois children and adults with epilepsy will soon be allowed to treat with cannabis.

 

http://news.msn.com/...n-with-seizures

 

 

Here's an 8 minute video of another recent child epilepsy success story

 

http://www.webmd.com/news/breaking-news/marijuana-on-main-street/medical-marijuana

Edited July 22, 2014 by Bob in Mich

[3rdnlng]

Some more good news. Illinois children and adults with epilepsy will soon be allowed to treat with cannabis.

 

http://news.msn.com/...n-with-seizures

Love your passion and will evaluate your links (somewhat). Your posting has started to become a crusade though. Might want to read your TOS too.

Edited July 21, 2014 by 3rdnlng

[John Adams]

Love your passion and will evaluate your links (somewhat). Your posting has started to become a crusade though. Might want to read your TOS too.

 

The TOS barely apply here and at least the stoner is trying to confine his unneeded crusade to a single thread.

[IDBillzFan]

I genuinely look forward to the day when pot smokers get the legal dope they insist is needed to help sick people, only to watch taxes and regulation blow prices through the roof for middle-class smokers.

 

Be careful what you wish for from the government, smokers, as you will surely get it.

[Nanker]

Welcome back HogBoy. It's been quite some time, hasn't it?

You sure do know how to string folks along. Your work is Crayonz worthy.

[Bob in Mich]

OK, if you have watched or read about cannabinoids and cannabinoid receptors, you now know that they are in animals too, including pets.

 

After the jokes die down, if you have an older pet with health issues, it may be worth further research. Note, I am not any sort of medical professional.

 

If your pet is tolerating its medicine well and it is effective, certainly do not change anything. At this point my non-professional opinion would be to consider this option when there isn't really much else that your vet can do.

 

DO NOT FORCE SMOKE INTO YOUR PET'S FACE. I am talking about cannabis based medicines, such as glycerin tinctures, for pets, especially pets nearing the end of their life. Or, the concentrated oil can be smeared onto treats or even right onto the teeth of a pet that has no appetite. It will be absorbed through the tissues in the mouth as it melts. Capsules can easily be made from the concentrates if your pet can take them. Start with the tiniest of dosages and work up to an effective dose.

 

Why would anyone do that to their pet, right? Well, as with people, it largely has to do with positive effects and lack of negative side effects.

 

The big three positive effects I suppose are pain reduction, appetite stimulation, and restful sleep. As with people too, an animal will need a few doses to get used to the medicine and may lose some coordination with the initial doses. Be careful around stairs or drop-offs. Watch the animal until it falls asleep. If given a large dose be watchful as the pet could wet the bed. They sleep very soundly and typically wake up, go outside to do some business, come in, and head to their food bowl.

 

I guess it shouldn't be all that surprising that veterinarians haven't started reusing it as medicine, at least the vast majority of them. Few enough doctors believe in the benefits and people are telling them directly. Not many dogs are talking, even after ingesting cannabis.

 

I want to mention one, certain to be doubted effect that I witnessed first hand. The concentrated cannabis oil, when repeatedly applied over the course of a month or two, can shrink mast cell tumors on the skin of a dog. My dog, due to anesthesia problems could not withstand more surgery. I had read about this cannabis possibility, had the oil on hand, and so started melting my dog's leg tumor over the course of six weeks.

 

When I returned to the same vet that had refused to remove the growth under a local, he was very surprised and wanted to know what I had done. I only took the dog to clean the wound because it now appeared that he was going to survive for a while and I was afraid that it might get infected. After cleaning up the wound area, the vet said, "the growth was now hanging on by a thread, so I removed it and sewed it up"

 

Several months later I had to put the dog down. Eventually his problems compounded and I couldn't take watching the struggle. On his last morning before our ride to the vet however, he had a good appetite.

 

------------------------------------------

Here were some historical veterinary uses of cannabis

 

http://antiquecannabisbook.com/chap14/Veterinary.htm

Edited August 31, 2014 by Bob in Mich

[IDBillzFan]

... may lose some coordination ... could wet the bed...will sleep very soundly and typically wake up, go outside to do some business, come in, and head to their food bowl.

 

This is also referred to around here as going full gatorman.

[John Adams]

Welcome back HogBoy. It's been quite some time, hasn't it?

You sure do know how to string folks along. Your work is Crayonz worthy.

 

Not sure anyone besides Chan is taking him seriously. Potheads campaigning for pot freedom don't get a lot of love here.

[Bob in Mich]

If you haven't reached my point yet, (even though I've been making it all along), I don't believe medical marijuana is as miraculous as you say. You claim it might cure numerous diseases, but I haven't seen the data for that. You say it doesn't have side-effects like vicodin, but I'm sure that will change as well.

 

Courtesy of drugs.com

 

Side effects of vicodin, just for comparison purposes:

 

 

Some side effects of Vicodin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

 

Applies to acetaminophen / hydrocodone: oral capsule, oral elixir, oral liquid, oral solution, oral syrup, oral tablet

Along with its needed effects, acetaminophen / hydrocodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking acetaminophen / hydrocodone:

More common

• Dizziness
  
• lightheadedness
  

Incidence not known

• Back, leg, or stomach pains
  
• black, tarry stools
  
• bleeding gums
  
• blood in the urine or stools
  
• blood in vomit
  
• bluish lips or skin
  
• chills
  
• choking
  
• cough or hoarseness
  
• dark urine
  
• decrease in the frequency of urination
  
• decrease in urine volume
  
• difficult or troubled breathing
  
• difficulty in passing urine (dribbling)
  
• difficulty with breathing
  
• difficulty with swallowing
  
• fast heartbeat
  
• fever
  
• fever with or without chills
  
• general body swelling
  
• general feeling of tiredness or weakness
  
• headache
  
• irregular, fast or slow, or shallow breathing
  
• light-colored stools
  
• loss of appetite
  
• lower back or side pain
  
• nausea or vomiting
  
• nosebleeds
  
• not breathing
  
• painful or difficult urination
  
• pale or blue lips, fingernails, or skin
  
• pinpoint red spots on the skin
  
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  
• severe or continuing stomach pain
  
• shortness of breath or troubled breathing
  
• skin rash, hives, or itching
  
• sore throat
  
• sore tongue
  
• sores, ulcers, or white spots on the lips or in the mouth
  
• tightness in the chest
  
• unable to speak
  
• unusual bleeding or bruising
  
• unusual tiredness or weakness
  
• upper right abdominal or stomach pain
  
• yellow eyes and skin
  

Get emergency help immediately if any of the following symptoms of overdose occur while taking acetaminophen / hydrocodone:

Symptoms of overdose

• Bloody or cloudy urine
  
• change in consciousness
  
• chest pain or discomfort
  
• cold and clammy skin
  
• decreased awareness or responsiveness
  
• extreme drowsiness
  
• general feeling of discomfort or illness
  
• increased sweating
  
• irregular heartbeat
  
• lightheadedness, dizziness, or fainting
  
• loss of consciousness
  
• no blood pressure or pulse
  
• no muscle tone or movement
  
• not breathing
  
• severe sleepiness
  
• slow or irregular heartbeat
  
• stopping of heart
  
• sudden decrease in the amount of urine
  
• unconsciousness
  
• unpleasant breath odor
  

Some side effects of acetaminophen / hydrocodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Drowsiness
  
• relaxed and calm
  
• sleepiness
  

Incidence not known

• Belching
  
• changes in mood
  
• difficulty having a bowel movement (stool)
  
• fear or nervousness
  
• feeling of indigestion
  
• hearing loss
  
• impaired hearing
  
• pain in the chest below the breastbone
  
• unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  

[John Adams]

The horse is dead troll.

[Bob in Mich]

This troll, me, has been a member on here since 2001 - about 3 years longer than you, Mr Adams. So, bite me. From my perspective you and Chano are the disruptive trolls in this thread.

 

For God's sake, 7 posts ago (just 2 of them mine), you defended my right to post here. What happened?

 

It is just information. Don't read the post if you aren't interested. How easy is that solution? Last I looked there were over 600 views so maybe there were readers that were interested other than you.

 

Was it the information on pets or.....Oh, I see! You must be a pharmacy rep and didn't like that tidbit on the vicodin side-effects, was that it?

Edited July 22, 2014 by Bob in Mich

[FireChan]

 

 

Courtesy of drugs.com

 

Side effects of vicodin, just for comparison purposes:

 

 

Some side effects of Vicodin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

 

Applies to acetaminophen / hydrocodone: oral capsule, oral elixir, oral liquid, oral solution, oral syrup, oral tablet

Along with its needed effects, acetaminophen / hydrocodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking acetaminophen / hydrocodone:

More common

• Dizziness
  
• lightheadedness
  

Incidence not known

• Back, leg, or stomach pains
  
• black, tarry stools
  
• bleeding gums
  
• blood in the urine or stools
  
• blood in vomit
  
• bluish lips or skin
  
• chills
  
• choking
  
• cough or hoarseness
  
• dark urine
  
• decrease in the frequency of urination
  
• decrease in urine volume
  
• difficult or troubled breathing
  
• difficulty in passing urine (dribbling)
  
• difficulty with breathing
  
• difficulty with swallowing
  
• fast heartbeat
  
• fever
  
• fever with or without chills
  
• general body swelling
  
• general feeling of tiredness or weakness
  
• headache
  
• irregular, fast or slow, or shallow breathing
  
• light-colored stools
  
• loss of appetite
  
• lower back or side pain
  
• nausea or vomiting
  
• nosebleeds
  
• not breathing
  
• painful or difficult urination
  
• pale or blue lips, fingernails, or skin
  
• pinpoint red spots on the skin
  
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  
• severe or continuing stomach pain
  
• shortness of breath or troubled breathing
  
• skin rash, hives, or itching
  
• sore throat
  
• sore tongue
  
• sores, ulcers, or white spots on the lips or in the mouth
  
• tightness in the chest
  
• unable to speak
  
• unusual bleeding or bruising
  
• unusual tiredness or weakness
  
• upper right abdominal or stomach pain
  
• yellow eyes and skin
  

Get emergency help immediately if any of the following symptoms of overdose occur while taking acetaminophen / hydrocodone:

Symptoms of overdose

• Bloody or cloudy urine
  
• change in consciousness
  
• chest pain or discomfort
  
• cold and clammy skin
  
• decreased awareness or responsiveness
  
• extreme drowsiness
  
• general feeling of discomfort or illness
  
• increased sweating
  
• irregular heartbeat
  
• lightheadedness, dizziness, or fainting
  
• loss of consciousness
  
• no blood pressure or pulse
  
• no muscle tone or movement
  
• not breathing
  
• severe sleepiness
  
• slow or irregular heartbeat
  
• stopping of heart
  
• sudden decrease in the amount of urine
  
• unconsciousness
  
• unpleasant breath odor
  

Some side effects of acetaminophen / hydrocodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Drowsiness
  
• relaxed and calm
  
• sleepiness
  

Incidence not known

• Belching
  
• changes in mood
  
• difficulty having a bowel movement (stool)
  
• fear or nervousness
  
• feeling of indigestion
  
• hearing loss
  
• impaired hearing
  
• pain in the chest below the breastbone
  
• unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  

 

I got trolled. ****.

[Joe Miner]

Will it also cure the Dicky Do disease that affects millions of men in this country?

[4merper4mer]

Will it also cure the Dicky Do disease that affects millions of men in this country?

 

Let me guess. You're asking for a "friend".

[GG]

This troll, me, has been a member on here since 2001 - about 3 years longer than you, Mr Adams. So, bite me. From my perspective you and Chano are the disruptive trolls in this thread.

 

JA joined in 2004. The previous JA incarnation has been around a bit longer.

[FireChan]

This troll, me, has been a member on here since 2001 - about 3 years longer than you, Mr Adams. So, bite me. From my perspective you and Chano are the disruptive trolls in this thread.

 

For God's sake, 7 posts ago (just 2 of them mine), you defended my right to post here. What happened?

 

It is just information. Don't read the post if you aren't interested. How easy is that solution? Last I looked there were over 600 views so maybe there were readers that were interested other than you.

 

Was it the information on pets or.....Oh, I see! You must be a pharmacy rep and didn't like that tidbit on the vicodin side-effects, was that it?

 

This just in, trolling and disagreeing are synonymous

[ExiledInIllinois]

Anybody mention obesity as a disease? Stoner's like munchies, snacks. The Mary Jane surely can't be helping that "disease" and gratuitous calories people will consume.

 

 

 

This just in, trolling and disagreeing are synonymous

 

So are multiple screen names.

[FireChan]

Anybody mention obesity as a disease? Stoner's like munchies, snacks. The Mary Jane surely can't be helping that "disease" and gratuitous calories people will consume.

 

 

 

So are multiple screen names.

 

Huh?

[Bob in Mich]

Anybody mention obesity as a disease? Stoner's like munchies, snacks. The Mary Jane surely can't be helping that "disease" and gratuitous calories people will consume.

 

 

 

Ask about obesity? Check out this article. Studies show that regular cannabis users are statistically less obese

 

 

http://www.cnn.com/2...etes/index.html

 

(TIME.com) -- Toking up may help marijuana users to stay slim and lower their risk of developing diabetes, according to the latest study, which suggests that cannabis compounds may help in controlling blood sugar.

Although marijuana has a well-deserved reputation for increasing appetite via what stoners call "the munchies," the new research, which was published in the American Journal of Medicine, is not the first to find that the drug has a two-faced relationship to weight.

Three prior studies have shown that marijuana users are less likely to be obese, have a lower risk for diabetes and have lower body-mass-index measurements. And these trends occurred despite the fact that they seemed to take in more calories. (continued at the link)

Edited July 23, 2014 by Bob in Mich

[Bob in Mich]

And this list of studies from the GW Pharmaceutical site http://www.gwpharm.com

 

 

Cannabinoid Publications in Metabolic Disease

 

 

The cannabinoid Δ(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity.

 

Wargent ET, Zaibi MS, Silvestri C, Hislop DC, Stocker CJ, Stott CG, Guy GW, Duncan M, Di Marzo V, Cawthorne MA. Nutr Diabetes. 2013 May 27;3:e68.

 

The endocannabinoid system in energy homeostasis and the etiopathology of metabolic disorders.

 

Silvestri C, Di Marzo V. Cell Metab. 2013 Apr 2;17(4):475-90.

 

Cannabinoids and Endocannabinoids in Metabolic Disorders with Focus on Diabetes

 

Di Marzo V, Piscitelli F, Mechoulam R. Handb Exp Pharmacol. 2011;(203):75-104.

 

Cannabinoids inhibit insulin receptor signalling in pancreatic β-cells

 

Kim W, Doyle ME, Liu Z, Lao Q, Shin YK, Carlson OD, Kim HS, Thomas S, Napora JK, Lee EK, Moaddel R, Wang Y, Maudsley S, Martin B, Kulkarni RN, Egan JM. Diabetes. 2011 Apr;60(4):1198-209.

 

A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans

 

Romero-Zerbo SY, Rafacho A, Díaz-Arteaga A, Suárez J, Quesada I, Imbernon M, Ross RA, Dieguez C, Rodríguez de Fonseca F, Nogueiras R, Nadal A, Bermúdez-Silva FJ. J Endocrinol. 2011 Nov;211(2):177-85.

 

Peripheral effects of the endocannabinoid system in energy homeostasis: adipose tissue, liver and skeletal muscle.

 

Silvestri C, Ligresti A, Di Marzo V. Rev Endocr Metab Disord. 2011 Sep;12(3):153-62.

 

Effect of dietary fat on endocannabinoids and related mediators: consequences on energy homeostasis, inflammation and mood.

 

Banni S, Di Marzo V. Mol Nutr Food Res. 2010 Jan;54(1):82-92.

 

Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice.

 

Riedel G, Fadda P, McKillop-Smith S, Pertwee RG, Platt B, Robinson L. Br J Pharmacol. 2009 Apr;156(7):1154-66

 

Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe?

 

Nunn AV, Bell JD, Guy GW. Nutr Metab (Lond). 2009 Apr 16;6:16.

 

Endocannabinoids, FOXO and the metabolic syndrome: redox, function and tipping point--the view from two systems.

 

Nunn AV, Guy GW, Bell JD. Immunobiology. 2010 Aug;215(8):617-28

 

The endocannabinoid system in metabolic control: a preface.

 

Di Marzo V. Best Pract Res Clin Endocrinol Metab. 2009 Feb;23(1):vii-ix.

 

Cannabidiol arrests onset of autoimmune diabetes in NOD mice.

 

Weiss L, Zeira M, Reich S, Slavin S, Raz I, Mechoulam R, Gallily R. Neuropharmacology. 2008 Jan;54(1):244-9

 

Cannabidiol lowers incidence of diabetes in non-obese diabetic mice.

 

Weiss L, Zeira M, Reich S, Har-Noy M, Mechoulam R, Slavin S, Gallily R. Autoimmunity. 2006 Mar;39(2):143-51.

Edited July 23, 2014 by Bob in Mich

[DC Tom]

We get it, marijuana is magical.

[IDBillzFan]

We get it, marijuana is magical.

 

Based on Bob's posts, I'd say the only problem with marijuana is that it doesn't come in the form of a breakfast cereal. How can something this helpful and nutritious NOT be poured out of a box to start everyone's day in the healthy, delicious way?

[Bob in Mich]

Funny you should ask.

 

Check out this link from Cheerios on a new cannabis based.....

 

ok, just kiddin, but now I can see that you are starting to come around

[TakeYouToTasker]

We get it, marijuana is magical.

No joke. It's a true panacea.

 

If only they smoked the garbage at the Fed.

[IDBillzFan]

Funny you should ask.

 

Check out this link from Cheerios on a new cannabis based.....

 

ok, just kiddin, but now I can see that you are starting to come around

 

I guess I'll never understand how something that is SO good for you turns its chronic users into blathering idiots.

[FireChan]

I guess I'll never understand how something that is SO good for you turns its chronic users into blathering idiots.

 

I think I'd rather have diabetes than be the guy who takes 20 minutes to order at McDonald's.

[Bob in Mich]

Believe me when I say this, Chano. After trying to respond to your postings here, I think I would rather you have diabetes too

[DC Tom]

No joke. It's a true panacea.

 

Right up there with cowbell.

[GaryPinC]

Ask about obesity? Check out these articles. Studies show that regular cannabis users are statistically less obese

 

 

http://www.cnn.com/2...etes/index.html

 

(TIME.com) -- Toking up may help marijuana users to stay slim and lower their risk of developing diabetes, according to the latest study, which suggests that cannabis compounds may help in controlling blood sugar.

Although marijuana has a well-deserved reputation for increasing appetite via what stoners call "the munchies," the new research, which was published in the American Journal of Medicine, is not the first to find that the drug has a two-faced relationship to weight.

Three prior studies have shown that marijuana users are less likely to be obese, have a lower risk for diabetes and have lower body-mass-index measurements. And these trends occurred despite the fact that they seemed to take in more calories. (continued at the link)

 

 

First off, your link doesn't work. Here's the actual link: http://www.amjmed.co...e/S0002-9343(13)00200-3/pdf Edit: This isn't working either. Go to AJM and search Murray A. Mittleman

Here's a CDC link with incidence of type 2 diagnosis by age: http://www.cdc.gov/d...cs/age/fig1.htm

I included the CDC link as a general relation of age related changes to body physiology

 

-The AJM study has 4600 particpation, 579 of which are current users which is only 12.2% of your study population to base your conclusions.

 

-45% of current users are under age 30, 60% of them also smoke tobacco, 77-78% of never or past users are over age 30 12% and 28% respectively smoke tobacco. Refer to cdc graph.

 

-Never used it is more racially mixed (~56% white) than past or current users (70-77% white).

 

-Currently using group is 66% male, 34 female. Other 2 groups are closer to 50/50.

 

-Directly from the paper page 586: Because people with diabetes mellitus may alter their marijuana use habits, we also performed a sensitivity analysis excluding participants with diabetes mellitus.

 

Hmmm. Not a huge percent of the study population but I do wonder if they also excluded diabetes participants from the "never used" group. Trust me, don't assume they did. Seems to me they could have addressed this in the survey! Certainly very convenient to exclude diabetes patients with their higher numbers from the much smaller "currently using" group.

 

-Non users have never smoked it, past users smoked from once in their life to not within the past 30 days, and current users at least once in the past 30 days.

 

So someone who smoked it once as a teenager and is now 59 is lumped in with someone who smoked regularly for years but gave it up 30 days ago. Not a good way to classify this group.

 

Sorry Bob, not the smelliest study I have seen but right up there. Physicians are required to have a certain # of research publications as part of their training and quite a few of them choose to pore over vast libraries of collected study data hoping to ferret out statistically significant correlations which may or may not be a false positive. Doesn't matter to them as long as it gets published. There's a good chance that happened here, And yes, it happens in prestigious journals like AJM all the time.

 

Personally, I don't put much weight in these results.

 

Your second reference with the pretty picture and orphan receptor has no relevance to the marijuana discussion from what I can see. Did I miss something about it?

Edited July 23, 2014 by GaryPinC

[Bob in Mich]

My cnn link worked just fine for me http://www.cnn.com/2...etes/index.html Edit: I understand now that you mean the link within the CNN article.

 

I had a non-cannabis article copied into my earlier post. You were correct. I had gotten carried away with my cutting and pasting and included a non-cannabis FOX article. Sorry about that and thanks for catching it. I have removed it. It was a cool picture though, eh?

 

Gary, if the study underlying the CNN article is flawed, I will take your word for it.

Edited July 23, 2014 by Bob in Mich

[3rdnlng]

And this list of studies from the GW Pharmaceutical site http://www.gwpharm.com

 

 

Cannabinoid Publications in Metabolic Disease

 

 

The cannabinoid Δ(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity.

 

Wargent ET, Zaibi MS, Silvestri C, Hislop DC, Stocker CJ, Stott CG, Guy GW, Duncan M, Di Marzo V, Cawthorne MA. Nutr Diabetes. 2013 May 27;3:e68.

 

The endocannabinoid system in energy homeostasis and the etiopathology of metabolic disorders.

 

Silvestri C, Di Marzo V. Cell Metab. 2013 Apr 2;17(4):475-90.

 

Cannabinoids and Endocannabinoids in Metabolic Disorders with Focus on Diabetes

 

Di Marzo V, Piscitelli F, Mechoulam R. Handb Exp Pharmacol. 2011;(203):75-104.

 

Cannabinoids inhibit insulin receptor signalling in pancreatic β-cells

 

Kim W, Doyle ME, Liu Z, Lao Q, Shin YK, Carlson OD, Kim HS, Thomas S, Napora JK, Lee EK, Moaddel R, Wang Y, Maudsley S, Martin B, Kulkarni RN, Egan JM. Diabetes. 2011 Apr;60(4):1198-209.

 

A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans

 

Romero-Zerbo SY, Rafacho A, Díaz-Arteaga A, Suárez J, Quesada I, Imbernon M, Ross RA, Dieguez C, Rodríguez de Fonseca F, Nogueiras R, Nadal A, Bermúdez-Silva FJ. J Endocrinol. 2011 Nov;211(2):177-85.

 

Peripheral effects of the endocannabinoid system in energy homeostasis: adipose tissue, liver and skeletal muscle.

 

Silvestri C, Ligresti A, Di Marzo V. Rev Endocr Metab Disord. 2011 Sep;12(3):153-62.

 

Effect of dietary fat on endocannabinoids and related mediators: consequences on energy homeostasis, inflammation and mood.

 

Banni S, Di Marzo V. Mol Nutr Food Res. 2010 Jan;54(1):82-92.

 

Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice.

 

Riedel G, Fadda P, McKillop-Smith S, Pertwee RG, Platt B, Robinson L. Br J Pharmacol. 2009 Apr;156(7):1154-66

 

Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe?

 

Nunn AV, Bell JD, Guy GW. Nutr Metab (Lond). 2009 Apr 16;6:16.

 

Endocannabinoids, FOXO and the metabolic syndrome: redox, function and tipping point--the view from two systems.

 

Nunn AV, Guy GW, Bell JD. Immunobiology. 2010 Aug;215(8):617-28

 

The endocannabinoid system in metabolic control: a preface.

 

Di Marzo V. Best Pract Res Clin Endocrinol Metab. 2009 Feb;23(1):vii-ix.

 

Cannabidiol arrests onset of autoimmune diabetes in NOD mice.

 

Weiss L, Zeira M, Reich S, Slavin S, Raz I, Mechoulam R, Gallily R. Neuropharmacology. 2008 Jan;54(1):244-9

 

Cannabidiol lowers incidence of diabetes in non-obese diabetic mice.

 

Weiss L, Zeira M, Reich S, Har-Noy M, Mechoulam R, Slavin S, Gallily R. Autoimmunity. 2006 Mar;39(2):143-51.

 

For your own sake don't ignore my earlier advice about crusading.

[Bob in Mich]

For your own sake don't ignore my earlier advice about crusading.

 

I find it odd that you have no issue with nonsensical postings about McDonalds queues, breakfast cereals, Dickey Do Disease, and magical cowbells but my post, technically a response to a question on obesity with links to research studies on cannabinoids, is the one that has ruffled feathers and has become problematic.

 

The information is contained within a single 'off topic' thread about cannabis and health problems. There is no board take over, turning every conversation to a single subject.

 

What is inappropriate about linking to research studies on GW Pharma site? They are probably the premier cannabis research company in the world today.

Edited July 23, 2014 by Bob in Mich