Look at the 1st round picks over the last 6 years:
Buffalo - Whitner, McCargo, Lynch, McKelvin, Maybin, Wood, Spiller
Green Bay - Aaron Rodgers, AJ Hawk, Justin Farrell, BJ Raji, Clay Matthews, Bryan Bulaga
Conclusion: The Bills have been the master of their own demise. Green Bay has succeeded because they pick better. The Bills could have had the starting right tackle in Bulaga but they preferred Spiller. They chose Maybin ahead of Matthews!
What wins in the NFL?
Talent.
Talented owners, talented GM's, talented coaches and talented players. The Bills fail on all counts.