La Conjecture strikes again!
Not in the Bills current system. He's basically a 1v1 swap with Jerry Hughes, so the question is how much better than Hughes is he and how much money/ trade capital is that improvement worth. Personally, I'm dubious that the upgrade would be worth what that they'd have to give up for him. I would imagine Hughes plus a #1, minimum. Next year's #1 might be a very high pick where you could get a guy like Mack without having to give Hughes up.