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Hapless Bills Fan

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About Hapless Bills Fan

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    I've Sworn an Oath of Solitude 'til the Pestilence is Purged

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  1. This is diverging from “Facts Only” since it’s my opinion based on my survey of the published evidence. I’ve said it before and I’ll say it again: I don’t think it’s coincidence that the places that have had the Best Luck reining this thing in are the places with a high incidence of public mask wearing. Initially, public health folks figured this Covid-19 thing transmitted like flu, where droplet transmission (doesn’t spread that far) and surface transmission are a thing. Now I think there’s a good bit of evidence that aerosol transmission is a thing. There is also IMO a good bit of evidence that people may be most contagious for 1-2 days BEFORE they develop symptoms. There are several very clear reports transmission where someone who was asymptomatic at the time spread the disease through aerosol transmission. Then there are the ijits like the Springfield, MO Great Clips hairdresser who worked for 8 days while symptomatic exposing something like 91 people (and visited Walmart, CVS, Dairy Queen, and a health club to boot) Given these things, the advice to wear a mask “only when you have symptoms” or “are in the presence of someone with symptoms” seems....Ineffectual....to me. First off, how will you know if you’re in the presence of someone with symptoms? And if you are, are they gonna do the right thing, or are they gonna boogie about snorting on you?
  2. First off, check your car insurance, it may cover a diagnostic visit and/or tow to the dealer if necessary. You CAN jump a hybrid, but often the batteries are in the rear (are on a Prius) and you need to know where the connection point is. Owners manual. hybrids have two sets of batteries, one that starts the car, and the batteries that can power the car to drive. One can affect the other. You might need either or both replaced but as has been said check warranty. May be covered. Good luck! We bought used 2010 Prius in 2013, has been good car for us we have had to have it jumped and have replaced the starting battery. Bigger job than in ordinary car as Some Dissasembly Required to access the thing.
  3. Well, yes but.....if your slogan is a mask for every American, that’s 0.3% of your goal
  4. I’m not interested at all in Moderna’s press release. Im interested in their preliminary phase I readout
  5. 45 of 45 subjects had antibodies. Only 8 have been tested for neutralizing antibodies so far. Neutralizing antibody tests require BSL-3 containment and take longer. I guess you have your expectations, and you're entitled to them, but that's pretty par for the course info on preliminary read out from a Phase I trial. Some of those experts are a bit unrealistic in their expectations for rapid and transparent data sharing by companies for a prelim. read on a Ph I trial. In my opinion. Now if the NIAID is conducting the trial, the NIAID should publish, and I'm sure they will, but not at a preliminary read out stage. All these guys are saying is that there isn't evidence that the vaccine is destined to work, and that's perfectly true (in fact, they make many of the exact same caveats I made in the post I linked for you) but it doesn't mean the data are unreliable. Some of them come across as a bit If your point is you think the company is manipulating the market to make money, that's probably true, but it doesn't mean the product isn't promising. It would be nice if the market were less easily swayed, but that's beyond my control or yours. I'm out of here, believe whatcha like.
  6. In response to my Facebook message asking when one might expect a mask ordered 24 April to be delivered, I got a polite regurgitation of the boilerplate on their website and the explanation it is first come first served, will get an email just before the mask is ready to ship asking to confirm shipping address etc. I said thank you for the response, but can you give me a rough idea when I should expect a mask ordered 24 April to ship? At that point they asked me what email addy I had used to order the mask. So if one of you gents has Facebook and wants to message them, I'd be interested in what you could learn (or if you care to PM me an email addy, I'll keep my convo going)
  7. Additionally, a player reportedly said O’Shea made the situation worse by trying to install especially complicated elements of the Patriots offense used by Tom Brady and Patriots offensive coordinator Josh McDaniels. So, Chan is back with Fitz now in Miami. That was my thought - we suffer from the same problem here.
  8. Player acceptance of this device should be high, especially among players who'd like to project that Bad Ass image. I can see linemen (both sides of the ball), linebackers, and running backs in particular wanting this thing.
  9. FWIW, I agree with both of you - "if we all wear masks, we all help each other" AND "most people are putting things on their face with no idea what the exact benefit is" (because mask studies of different materials for blocking outward transmission are not very thorough or great) If it helps society open up and STAY OPEN, seems to me like a little discomfort from masking-up in the social good is worth the attempt. I can't believe how many people are just SEPTIC about it "doesn't block virus" "blocks oxygen and CO2" (amusingly, sometimes from the same people - make up your mind, folks) "interferes with my erectile function and causes leprosy" but I suppose I shouldn't be so surprised - I do remember all the kerfluffle when mandatory seat belt laws began to be passed. There was all kinds of stuff that has been disproven "better to be thrown clear" blah blah and all kinds of objections.
  10. Um, no one is telling you that? But that's because it's the nature of a Phase I study to "not amount to much of anything", not because "Moderna and other manufacturers are the last source" to rely on when presenting clinical trial results. Phase I clinical trials are the lowest bar. It's testing safety at different dose ranges in a small number of healthy volunteers. Vaccines have the benefit of being able to look for antibodies, which is more significant than you think - inability to elicit an antibody response period has been a stumbling block of this whole RNA/DNA vaccine technology - but antibodies may or may not correlate to disease immunity.
  11. It needs to be borne in mind that Abbot's antibody test and their standard RT-PCR test are some of the best out there. The problem seems to be their rapid-test ID-Now technology. Things don't always work in the field like they do in development, and you have to get 'em out in the field to see. Moncef Slaoui was head of vaccine development at Glaxo Smith Kline before he worked at Moderna. He's probably one of the most qualified scientists on the planet that could be tapped for the job. I can think of maybe 3-5 others that would be arguably as qualified, and that's it. Should he divest his stock options, yes he should and he's said he will. I think you're skeptical of the wrong things, myself. If Moderna's vaccine pans out and gets scaled up in manufacture, it will be because there is overwhelming evidence it is effective. What I have more concern about is that another vaccine, such as Oxford University's, will actually show better efficacy and sooner but we won't approve it for use in US because they won't grant an American company an exclusive license to manufacture and market it. THAT'S the factor to watch IMO, and scream about if it goes down. Even so, the chance will be there (for any vaccine) that some side effect will crop up that was not seen in clinical trials, which are going to be rushed and abbreviated in this instance.
  12. It's a real concern always, to balance safety and speed, and the FDA's recent track record with testing gives rise to legit concerns about judgement here. I would say the results are legit. It's not like Moderna or other manufacturers are doing clinical trials in some kind of hermetically sealed dome. They're in multiple sites, in multiple parts of the country, some being administered by universities, some by clinical trial organizations that are typically separate from the company itself - especially a small company like Moderna, which doesn't have an existing clinical trial organization on standby for whenever they might have a product to trial. (and even big companies, these days, outsource) Like the meme says, people who posit grand company-driven conspiracies never actually managed real people on a real project. To dismiss such results as "last source I will rely on", frankly, is not common sense. To put the results in perspective is appropriate, though. They found antibodies in 45 people. Do the antibodies protect against disease? How long do they last? Will the same dose raise antibodies in people beyond the "young and in peak of good health" group? Will eliminating the high-dose arm suffice to alleviate the adverse events? Will a larger study turn up unacceptable adverse events? That's where you need to keep a careful watch, not on dismissing the results simply because a company is involved.
  13. I admire your chutzpah. Having worked on vaccines for a portion of my career, I would not put any amount of money on it, nor do I think it's "fear journalism". I think it's probable that there will be a vaccine by next summer, but not certainty. For all we do know, there's a lot we still don't know about the human immune system, and the vaccine candidates that are fastest in development are technologies with limited track records. Traditional vaccine candidates may take a bit longer, if we must go that route.
  14. Yes, that would be accurate. Yes, 18 months is optimistic. There are a few things working in favor of optimism: 1) Vaccine developers have been aware for years of the potential for an emerging disease to become a pandemic, and have been working hard on platform technology that can "plug in" information from a new disease into a developed platform and scale it up quickly. Many of the early vaccines are of this variety - mRNA or DNA vaccines plugged into an existing vehicle and formulation and making use of platform potency and release tests. So you might say that portions of the technology intended to be used, have in fact, been in development for years. They benefit from the learnings there. For example, Moderna struck out with several earlier vaccines and changed its platform accordingly. 2) The effort being put in. 3) The risk/benefit assessment - if you're trying to make a vaccine for a non-fatal, non-epidemic disease and the clinical trial has an arm where 3/15 patients have a serious reaction, you probably back away. For an epidemic disease, you say "OK, they weren't THAT bad, try a lower dose next time"
  15. I also may have a few sources remaining. I neither confirm nor deny this. Too early for release of peer-reviewed studies, but it's actual data, not PR releases. Can't help what Wall Street loves or dislikes.
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