GaryPinC

What I'm seeing from lab studies is that the mRNA vaccines that modified the spike protein (pfizer, moderna) are effective against UK, Brazil but lose something like 12 fold effectiveness for the S. Africa variant. J&J, Novavax have even more S-protein modifications so they may perform better against S. Africa. Keep in mind that current Russia, China, Astra Zeneca vaccines use the non-modified spike protein and may have decidedly less efficacy. Supposedly Moderna or Pfizer has already sent FDA a modified vaccine dose they feel will be more effective against the variants. Not sure if this is different from their next-gen vaccine of the receptor binding domain (RBD) already in clinical trials. Sorry, no citations, saw this in browsing articles last night and this morning.

https://www.nature.com/articles/s41577-020-00480-0/tables/1 Fantastic article discussing the major vaccines and this table 1 link really highlights how the US/Europe has the best ones. Truly impressive Pfizer and Moderna took the extra scientific steps to design a more effective spike protein antigen in such a short time. Please everyone get the vaccine, I got Moderna, nothing too bad but mostly some transient chills/fever 13-18 hours post-second dose. This vaccine is nothing more than an mRNA surrounded by nano-lipid (fat) molecules. Side effects are consistent with a viral immune response and I think Moderna pushed the dose level given the urgent need. Side effects I take as a sign the vaccination was successful the first dose.

Great cover 1 article Yolo, thanks for posting. The future's bright for AJ, he's a tireless worker and I think his specialty is getting inside effectively from that DE position. In college, he used his strong hands and arm thrusts at a heavier weight to be effective in the big 10. In the NFL he needs to be effective on the outside and use it and more burst to set up his inside game. But he's very intelligent and tireless. The next two years will be fun to see where he ascends. I expect him to be a disruptor and you get Ed Oliver upping that part of his game, it should create havoc for offenses.

I hope you don't let it bother you too much. Abused dogs carry quirks and emotional scars and sometimes nothing can change that. Sometimes you can work around those and other times you can't.

There is most definitely an endgame. We are going to vaccinate Covid-19 either to obscurity (polio, smallpox) or to a manageable level in society (influenza). My guess is somewhere in the middle of this spectrum, either several years of adapted vaccines or a paradigm similar to influenza but maybe less often. Right now, even though the MSM will be histrionic about mutated Covid, it does appear Covid mutates faster than previously thought. Not as fast as influenza though. And while the vaccines may have some degree of reduced efficacy, they are far from impotent against the mutants. We are all tired of the precautions, so start by getting vaccinated at first opportunity. Natural immunity and vaccinated immunity are critical. We are privileged to have the finest vaccines here in the US and if anyone prompts me I can explain why. As the numbers change, so do the restrictions. We need to use the vaccines to reduce the spread and concurrent natural mutations, then the numbers and science will dictate what kind of long term vaccine plan is necessary. In fact, once the numbers and epidemiologists determine vaccine and natural immunity have reduced spread of the virus enough it will be critical to remove precautions to assess the long term health plan to prevent Covid from ever threatening our health care system again.

Schools are open. Not everywhere, but in very many states, including mine (Ohio). Classes are masked and socially distanced. Part of how they managed to do this is because a significant number of parents CHOSE to keep their kids virtual. Sports are being played. What the science says is that kids 15 and under are less likely to be infected and spread Covid. Kids under 12 especially. The science also says that primary school kids are far more likely to be mild or totally asymptomatic. The science also says that infected kids above 15 spread the virus akin to adults, thus the risk to teachers. The science is also showing in open schools with Covid precautions there are very few spreading events. Hence the CDC and everyone pushing for schools with proper precautions to be open. The science also shows that some kids do better at virtual classes, others better in-person. See the entire science instead of just the parts you like.

Well, congratulations you're both correct!

Yep, only reason I am rooting for Tampa is KC's defense got away with a ton of holding against us and happy to see it called right this week.

Sums it up even nicer in that if Edmunds hadn't bit hard on the play fake he's one step closer to Hill to make that play or even defense the pass.

Your logic is extremely flawed. It's relatively simple. It'll be over when the hospitalizations, deaths, and new cases decrease and stabilize. As vaccinations come up and cases go down precautions are relaxed. If everything stays stable we continue to relax precautions until we're done with masking and distancing. How soon is difficult to predict but we know it'll happen a lot quicker if everyone gets vaccinated. Personally, somewhere between end spring and fall for a return to normalcy seems reasonable right now. It's not about stamping it out. It hardly ever was. It's about having it under control.

It's already been explained to you, weeks ago. But you are so steeped in your own ignorance any further effort seems pointless.

community health centers opposed the Trump administration plan. “The executive order was a slap in the face because we were already a low-cost alternative to high prescription drug prices. The executive order just created massive red tape. It’s not a good rule.” See my post from yesterday for the rest of your answer. But I've copied the important part here to hopefully help your reading comprehension.

Ah, subjective judgement from your own brainwashed politics of idiocy.👌

“Their whole mission for 55 years has been to provide low-cost prescriptions and services to low-income families,” said NACHC vice president of media relations Amy Simmons Farber, who also said community health centers opposed the Trump administration plan. “The executive order was a slap in the face because we were already a low-cost alternative to high prescription drug prices. The executive order just created massive red tape. It’s not a good rule.” https://www.wtsp.com/article/news/verify/verify-biden-administration-insulin-costs/531-57ea96f8-bcbf-412e-8d25-6aaaa37319b4 I personally believe Trump was trying to do the right thing on this. executive orders: I'm not a big fan of them but it's traditionally used. Teddy Roosevelt used over 1000, FDR over 3700 his 12 years! https://www.presidency.ucsb.edu/statistics/data/executive-orders

Actually, I don't think this is correct. Edit: Young children seem less likely to catch it but this does not apply to older kids. Kids are much less likely to experience symptoms, especially severe, but can still contract and spread the virus is my understanding. Subtle but big difference, especially as many kids know Covid won't have any serious direct effect on them. Also, CDC is saying schools can be open with precautions: https://www.usatoday.com/story/news/education/2021/01/27/covid-schools-cdc-reports-how-classes-can-safe-prevent-spread/4278356001/ I know my local schools have done a good job with it and looking at their data there have been no significant outbreaks when the schools are open. I most certainly agree that the vaccine is the only way out.

And why isn't Kellyanne defending herself?

It was really surprising to me to see how leaned out and muscular Epenesa was compared to his Iowa years. I think his body fat % went way down and bulking muscle up during the season has to be a pretty tall order. Looking forward to see where his weight is at next year, and it will probably be all muscle. He played violently at Iowa, he may take a nice jump for us next year.

When it comes to politics the Post is NOT a legit news source anymore. They were/are no better than tabloid trash for anything Trump. Same with the NY Tmes and CNN. Just completely unprofessional, I lost all respect for them. It's a big part of the reason so many on the right turned so hard to the alt right news sources. Who stretch their own truths. And all this is a big reason the country is so divided.

More than sad. It's feeding towards dictatorship.

The answer as to why it made sense for the Dems to do it is contained there. They could easily have taken the more painful route if they chose.

The biggest thing for me with Biden is to keep his word on bipartisanship and unlock Congress. He's off to a good start. https://www.msn.com/en-us/news/politics/mcconnell-relents-on-senate-rules-signals-power-sharing-deal-with-democrats/ar-BB1d5y4q?scrlybrkr=3d4498da&ocid=uxbndlbing Did the Dems need to do this? Nope and small minded people would point to the past as an excuse not to. But, confirming there's an adult leading the white house making the kids on either side play nice. https://www.msn.com/en-us/news/politics/white-house-signals-it-could-agree-to-more-narrowly-targeted-stimulus-checks/ar-BB1d6V4g?li=BBnb7Kz Yep, Trump wanted the full 2k also. Definitely target the people who truly need it the most and cut the price tag. Win-win. Clearly a huge benefit of Biden's age is he remembers the value of negotiations. Encouraging, let's hope he sticks with it.

I'd like to see them trade Edmunds as I think his value is maxxed thanks to the pro-bowl nods. He's been more physical in the playoffs but has no instincts for the game, as others have said. Constantly being fooled and hoping his athleticism can make it up. While I felt he was more physical in the playoffs, he's still below par with it. If he's staying, I think you move him to an outside spot and simplify the game for him and see if it helps. Also, maybe his shoulder still isn't 100%? Oliver, I'd like to see him with a space-eater in the middle. He's shown he can make some strong plays. Epenesa is reworking his body, way too early to pass final judgement. He's really reshaped so credit his dedication.

good post, OP. A couple of observations/gripes: 3rd down RPOs to the right where Josh elected for the short throw instead of the handoff to Yeldon: the Yeldon run was there both times I noticed, especially the second one as the RG and RT sealed beautifully and it would have been a long gainer. Probably on Josh but also Daboll for not using that more. KC D was very grabby to slow receivers down in their patterns. Refs allowed it. They also jammed receivers intermittently at the LOSR. We did almost nothing. Why the hell can't you have our DE's clock Kelce every time he's over them? Why not intermittently jam their receivers? Throw off their play timing. I noticed the one time where Kelce got jammed and Mahomes struggled on the play Why did our DBs not get grabby with KC since refs were allowing it? How do we watch so much film but not scheme to stop that shovel pass near the goal line? Romo did a great job of highlighting how KC likes to run a lot of noise in terms of personnel but very much get the ball to the same places on the field in given situations. Just can't understand how this wasn't coached for at the Pro level. Our offense got mostly shut down all playoffs. AFC championship, even the entire playoffs, you need next level coaching to pull out all stops and try unique things against your opponent. Especially on defense. Josh needs to grow some more. We need more talent on D, especially our front line. Our coaches need to grow up also, but Frasier may be incapable. I feel like he likes to sit in a base defense just too much with little adjustment to the opponent.

I can't speak for Trump supporters, and as I wrote, it seems like you and I are mostly on the same page. What Biden did is wrong, understandable to an extent given the circumstances, but even he knew it and made amends for it. Your point about Trump plays into my greater point, instead of making excuses for Biden or denying the reality of the situation why not acknowledge his wrong and instead focus on what he did right? How much stronger is your argument by acknowledging the reality and then turn it around and ask Trumpies if Trump would have been strong enough to apologize in the same circumstances? No reasonable person can say yes. And on some level we are all reasonable. Both the left and the right share equal efforts to deny reality and pick at isolated details to try and rewrite reality and mostly miss what's really important. Kind of like Trumpies won't acknowledge that his role in January 6th was just plain wrong and he is at fault for helping incite it. For America to heal, we need to do better than this. That is all.

I'm not ignoring it at all. All the facts point to the truck driver was most likely not drunk. It's the gossip that clinches it for Snopes to absolve Biden. It's a fact that Biden also called the family years later to apologize. I see no mention of it, but undoubtedly Biden found out the results of the accident investigation. The facts show the driver made a strong effort to stop. Stating that the driver was drunk is lying. There's utterly no proof that is a true statement and all the available facts tell a different story. A neutral, reasonably intelligent person of good conscience would not say it. I think Biden is overall a decent guy and the emotional tragedy biased him. I'm not here to crucify Biden as I understand where he was coming from, and to his absolute credit, he apologized and stopped saying it. That's what means the most to me. In this right vs left mental diarrhea, the saddest thing is watching one side point fingers at the other while never pointing inwards first.