The Springs is higher than Denver. I've lived here for decades and the altitude is weird. It affects different people in different ways.
Young people (kids) it can hit real bad. Some older people (my parents visiting) it didn't effect at all. Bad headaches are common.
As for athletes, what we hear is even a drop of a few percent of competitiveness can give a team like Denver an overall advantage.
All sports teams are aware of this and I'm sure the Bills have a plan in place. I wish I could go to the game.........that hurts!
One of the funniest things is alcohol consumption! Come up here from sea level and you get hammered real quick.
When I go back to sea level for the first few days I can hardly get a buzz!