Since you can now set pre-snap adjustments for defensive player assignments, set a double- team on Harrison manually on every passing down, have your MLB drop into medium middle zones often, put your best corner on Reggie Wayne (since you're doubling Marvin), and rush with a DL. If your DL does not pressure the qb, try to stand your man up and jump as Manning begins to throw. This strategy will basically challenge the colts to use Edgerin James to beat you (which he still could )