Whoever said pressure doesn't work against Brady is wrong. We've seen teams give him trouble - not often - but we've seen it disrupt their offense. He doesn't throw picks but it's the only way to have a chance.
The issue is two fold - one, that's not what this years Bills team does well, so we may struggle to do it. Second, they'll still score and we'll ultimately have to outscore them, again not something we do particularly well.