Penalties can't be challenged, one way or another. I read that the people reviewing the challenge system discussed this in the off season but decided that it would open up a giant can of worms if you could challenge them so they don't allow it.
Rex needs to channel his inner Vince Lombardi and ride the team hard this week. Lombardi's philosophy was to build the team up when they were struggling to boost their confidence and ride them hard when they were doing well to avoid complacency. If Rex rides them hard this week I think they'll be ready to prove something for him vs San Francisco.
Where are the points going to come from? Watkins is out, Clay is out or practically out, Tyrod has been struggling passing... so forget the passing game. Do you think NE will be sitting on McCoy?
Bills are going to need some luck tomorrow.