Data is our friend (so is science btw):
"Since the NFL expanded to 12 playoff teams in the 1990 season, clubs coming off a first-round bye are 64-55-3 against the spread (53.8%) and 91-31 straight up (74.6%). Since 2015, those marks have jumped to 13-8-1 ATS (61.9%) and 18-4 SU (81.8%), including a 7-4 ATS / 10-2 SU run for No. 1 seeds."
https://www.thescore.com/nfl/news/2280404
Also relevant and possibly mitigating these numbers is that there has been a very recent 2 year trend of "road field advantage." Last season was the first year in NFL history where the road teams won more games than the home teams... 128-127-1 (.502). This season, home teams had a slim advantage, 137-131-1 (.511).
https://www.washingtonpost.com/sports/2022/01/14/nfl-home-field-advantage-pandemic/