I'm so sick of the claims that the Bills would never win versus ABC opponent if XYZ doesn't change. It is a bunch of bologna. The Bills just beat the best team in the NFL. They also beat the top seed in the AFC. It is a week to week league and every team is dealing with injuries, not just the Bills.
They'll adjust and figure it out. Or they won't. Injuries suck, but they are a part of the game. Get as high of a seed as you can and try to go on a run in the playoffs.