I am of the school you first need a great QB but baring that, one wins in the trenches so its OL and DL first...absolutely against a RB in the first two rounds..unless of course the next OJ (sans sharp edged weapons) is available when you pick
Do NT/DE, OT with first two picks, then in second go for a WR, LB, DB ( from the BPA list in the 2nd round)