It seems it's the Bills luck to have key injuries either before the season or at some point early on in the season which has a significant impact on the Bills playoffs hopes. Last year, it was Reggie Ragland, Shaq Thompson (for most of the year) and Sammy Watkins.
Which players can the Bills not afford to lose to injury?
My choices are: Tyrod Taylor. If he goes down for significant amount of time, the Bills are toast. Without Taylor, the Bills are a 4-12 team (at best).
LeSean McCoy
Sammy Watkins
This one is hard to nail down, but I'll say more than one injury to the defensive front four. I think they could get away with one player being hurt as it seems like they have good depth at those positions, but any more than that, then there's problems.
Micah Hyde