My take:
We have glaring holes in our secondary, a potentially top 5 d line and a linebacker core highlighted by a potential superstar in the making, Kiko Alonso.
I think the plan of attack will/should be a relentless blitzing attack on Brady, and conservative prevent style in the secondary. Let them beat us with short plays, which they're willing to do, but they won't be scoring 20 points in 2 minutes like they've had in the past.
This, coupled with a mega fast offense could see the Bills pulling in close toward the 4th quarter.
...Or it could be an absolute slaughterfest with a rookie QB, coach, OC and weak corners.