2008, Week 8: The 5-2 Bills are destroyed, 26-17 (it was worse than the score indicates), by the Jets. The Bills turn it over 3 times, Edwards is sacked 5 times, and the Bills accumulate under 300 yards of offense.
2011, Week 8: The 5-2 Bills are destroyed, 27-11, by the Jets. The Bills were down 27-3 until they scored a garbage time TD with a couple of minutes to go. 3 turnovers for the Bills, and the Bills accumulate under 300 yards of offense.
2017, Week 8: The 5-2 Bills are destroyed, 34-21, by the Jets. The Bills scored two garbage time TDs in the last four minutes. 3 turnovers by the Bills, and Taylor is sacked seven times. Due to a stellar garbage time performance, however (onside kick recovery!), they manage to accumulate 307 yards.
In 2008 and and 2011, complete meltdowns ensued after the losses to the Jets.
(And don't get me started on the second Jets game of 2008--the Losman fumble game.)