Zo only started 26 of 48 games in his years under McD. I would say the opposite of your premise, the Bills played 3 LBs in 2017 and 2018 because they had issues at Nickel until Taron Johnson took the job full time in 2019.
Yet one can look at Carolina where McD successfully used Keuchly, TD and Shaq Thompson at LB in a replica of Jim Johnson’s Eagle D. Maybe he will use more of a 3 LB set this year.