Don't forget "Black Friday" as the only game being played that day. Bills vs Chiefs would be a good spot for this if the league wants Buffalo to have a primetime game on Thanksgiving weekend.
Is the "Black Friday" game the day after Thanksgiving going to be a regular thing now. The Dolphins and Jets played it last year. If it is I could see Bills playing in that as well.
Nobody could predict he would last only 4 plays. This year the Jets are the most serious challenger to the Bills for the division IMHO. That is another reason I think one of the two games get on primetime.
I think they open at home. 1:00 game vs NE. Bonus prediction - Bills will wear all whites for the home opener
Primetime games
Jets - Allen and Rodgers (MNF)
at Ravens (SNF)
at Texans (MNF)
49ers (SNF)