Yes they do.
Look at the difference in playoff paths. Biggest Bills game in memory.
If Bills beat Bengals and Patriots:
Wild Card: bye
Divisional: home vs. Jaguars (or Titans), Ravens, Chargers, or Dolphins
Championship: home vs. Chiefs or Bengals
If Bills lose to Bengals:
Wild Card: home vs. Ravens or Chargers
Divisional: on road at Bengals
Championship: on road at Chiefs