I think you're right in that earning a LATE first round pick, which every team should strive to do, presents novel challenges each year. And this year's draft might be uniquely challenging once they get past the dozen-or-so blue chippers.
Moreover, I'll bet the 32 NFL draft boards this year are more varied and subjective than ever before. We might see the pundits and fans alike caught off-guard by more picks this year, as the prospects' draft profiles don't have the same degree of standardization (which was already subject to considerable variance) that teams have grown accustomed to. We're likely all a bit more clueless than usual about the actual inner workings of this year's team-specific draft evaluations.
Seems like this is a year to let the draft play-out in front of you. Some highly-rated talents WILL fall, seeing as the prospect ratings from team-to-team will be less consistent.
The draft should NOT be about immediate upgrades in any year (QB aside). It's about long-term roster building for the most part. Gotta keep cool and patient. Unless of course one of those top-fifteen (in the Bills' eyes) blue-chippers plummets. Then maybe they deal up. But I don't favor that approach.