On January 19, 2017, he was hired by the Buffalo Bills to serve on Sean McDermott's staff as offensive coordinator.[10] On January 12, 2018, Dennision was relieved of duty as offensive coordinator after thinking that bubble screens to Mike Tolbert were a good idea. Dennison also thought it was a good idea to try a screen pass to the fullback Patrick DiMarco on 1st and 10, on an important second half drive in a week 16 game against the Patriots. Predictably, the play went for an 8 yard loss.