The missing info is the quality of the pass catchers I think... obviously if you have a back comfortable catching passes and productive in YAC targeting him at a higher rate would make sense
My guess in increasing specifically the Bills' rate of targeting RB would be more in service of system-specific results...keeping a back in on pass downs to leak out for check down occupies a LB or safety, setting up wheel motion to disguise something, etc
I don't think there's any real need to get the ball in the hands of RBs near the LOS otherwise, esp in our offense