I think Spiller is the easiest, quickest answer to both questions. EJ is an injured rookie starting his first pro game against a team that has completely dominated the Bills for years. The most you can hope is he doesn't make any screw-ups that cost the game. Anything more than that is a bonus. This is where CJ needs to take as much pressure off EJ as possible.
The more Spiller can bang out plays and eat up clock and keep chains moving, the less exposure the defense gets against Brady. I really feel that for the Bills the running game is the only shot at winning, and everything else revolves around that. Defense MUST make some plays and keep the score down. We can edge a low-scoring game, but if Brady and his pals get rolling and its a shootout - no chance.
Honest question: would you put money on him doing that? Because until he actually does it in big games, and consistently, the questions will be asked.