I think the Bills have to focus on O-line if they are going to be serious about winning.
Consider this—NE and Brady were brought up earlier in this thread: how many top-flight receivers has NE/Brady had over the years? A few, but it certainly has never been a strength of their team. But what has been the consistent during the Brady years? Answer, a very strong (effective) offensive line. The lines—both sides—are the heart and soul, the core, the foundation, etc., of any good team. The Bills have made some decent picks in the o-line over the past few years (Glenn, Wood, etc.), but it is still an area of need that needs more help and needs to get better. And until it is addressed, this will be an area of inconsistency and frustration at best.
Anyhow, if one of the big three tackles is there, draft one. And, if a starting quality lineman is available in the 2nd or 3rd, draft them as well.