Since the advent of the 4-division system, the #5 seed wins the Wild Card game slightly more than 50% of the time...which makes a certain sense, since it's a match between the strongest non-division winner and weakest division winner.
On those grounds alone, I'm hopeful...but honestly, it's a coin-flip, and we still have a week of regular season football to go (where people can get injured - if they play Tre White next week, I'm going to have a heart attack.)