Depends on what game you want to go to. Secondary prices for New Orleans and Tampa will be pretty affordable, as most likely will the December games.
If you go to a later in the year game, visitor side gets the sun and can be much, much warmer than Bills sideline.
As you will see the day after the opener as someone will whine about it, the lower bowl pretty much stands all game. I like that, others hate it. But if you hate it, dont buy there.
I personally do not like the endzone seats, but think we have several posters who love them.