Interesting points.
I have concerns about the OL not being on the same page, though. A grossly missed assignment - especially with high crowd noise inhibiting QB playcalls at the LOS - can mean a straight shot to a QB by a large person.
An offense with long experience working with each other, a wizened QB is a different situation than the current Bills' offense. I understand how it can throw a wrench in a D's set and substitutions. I guess it comes down to to risk/reward guess.
I also think a no-huddle diminishes the role of the QB as the "field general". His force of personality to inspire and direct the troops, so to speak, - to admonish this wr to turn around an look back for a relief-valve pass, tell a back to watch out for that LB I saw creeping up last play etc.
There's an old saying:
"A General is but a fighting man, who happens to have an army at his disposal."