Well yeah the 2009 Monday Night game is obvious.
Both losses in 2012 get honorable mention though:
Week 4: I think we were both 2-1 at that point. Were up 21-7 in the 3rd quarter, it looks like maybe were overcoming this monkey. All of a sudden Brady goes off for like 5TDs. 52-28 final score.
The 2nd meeting that year: Bills down 37-31 with like a minute left with the ball in the red zone. Fitz looks for TJ Graham and gets picked. End game