AND ANOTHER REASON !
Plays are getting sent in late on the road in load stadiums (e.g. Houston).
As reported on OBL, they mention and explain why it gives the defense an advantage. Typically the offense has only 12 sec or so to execute the play.
The no-huddle / up tempo offense literally cannot be run in that situation- with JA calling the plays and Bills not substituting they will have a heck of a rapid fire approach and tire out the defense.