Hell, Philly did that on the deep over into Ras al'Ghul's zone to Devonta early on when they got the look they wanted. When they needed the big play to get back into the game, the hit exactly the same play again, the Bills still hadn't picked up on it.
I do think there's a good chance for Reid to pick up on that weakness and attack the same way, and if I know the Bills defensive coaches, they've spent 4 years running it back as if "this time it'll work" like Bullwinkle.