This was a huge week for Beane. Again, my plea is to let all of them play and play right away. With 3 early losses and a tough schedule to go, you can't afford to not put your best guys out there. Even if all 3 take 20 or less snaps on Sunday, I think you have to get them out there and let the most talented players (all of whom are good schematic fits) do what can do.
Douglas really would be vital against the passing attack of Cincy. You can't just throw anyone out there against that team and take your chances. He's the guy I most want activated.
Joseph can help with the aggressive running style of Mixon. Clog up lanes and don't let him get a full head of speed and knock over an undersized linebacker for a gain of 7. Get to him early.
Fournette you can probably go without this week but it's not like Murray has been giving much and it's not like there are a bunch of nuances to the Bills running game