It has been brought up a few times so I went to see the Titans offensive personnel grouping frequency.
They run a 3 or 3+ WR set 65% of the time so far this year so I expect the base to still be 4-2.
Titans run 12 (2 TE sets) 21% of the time.
That being said Taron Johnson will probably have to keep an eye on personnel changes and clear the field for Klein when needing to.
At least that's how I would think it will go.