Other than the obvious penalties and turnovers, from a tactical stand point I think stopping the Texans running game is key. The games the Bills have struggled in are ones that the opponent was able to run the ball right at the Bills. So if I was Houston, this is what I would try to do against this defense. The Bills defense has struggled at times this season against the run. Houston is 15th in passing yards and 9th in rushing yards so this also falls into what they do best on offense.
Also, something to consider, half of the bills games this season came against defenses that ended in the top 10. The Texans do not fit that mold! the Texans Defense has given up a lot of yards this year. They are ranked 28th overall, 30th against the pass and 25th against the run while giving up 19th highest points. This could be a decent opportunity for the Bills offense and while JJ Watt returning is something to talk about I think we can also talk about how healthy he really is.
Go Bills