I live here in Indianapolis, and I think there is a good chance that the Colts may just do something about it. They are sort of like the Bills in that they like to talk about what good "character" all their players have. And they, and the media, especially like to contrast that with the city's other pro sports team, the NBA Indiana Pacers, who continually embarrass themselves by off-the-court behavior (not to mention on-the-court incompetence). They've cut several players in the past for off-field incidents (Dominic Rhodes for a DUI right after he played really well in their Super Bowl victory, and a starting defensive lineman whose name escapes me for pot possession).
Anyway, Polian was interviewed on the radio this afternoon, and sounded pretty pissed off that he even had to deal with questions about something like this (especially during their bye week). At the very least they are likely to fine Macafee substantially ... and might even suspend him for "conduct detrimental". They'll probably wait to see what, if anything, Goodell does first.
GO BILLS!