His high was 24th in QB DVOA, which he reached after the Cowboys game. Not sure what you're referring to - maybe ESPN's QBR?
?? -- measuring, say, a defense by team wins and losses won't tell you much if the offense and ST are terrible.
If they were playing in Buffalo, I would be very confident. The fact that they are playing in Pitt, that Pitt is on a big run, and that Pitt's D now has elite-level personnel with the addition of Fitzpatrick makes me worried. I still think the Bills are the better team and should win, but since they've historically struggled quite badly in Pitt, I think it's a toss-up.