I understand where you are coming from.
No position except QB really makes that much of a difference.
That said however, losing Edmunds and Milano at the same time will be a challenge. It immediately exposes the weakest backup situation on the team.
I hope McD and Frazier scheme something to cover for the lack of ability of Klein and Dodson. However creativity is not a strong suit of either McD or Frazier. I suspect they will roll out the standard defense and simply take a next man up mentality.