Well I do want a QB, but he may not necessarily be there this year. IMO, the Bills have 2-3 drafts (at least) where they will compete for the top overall pick.
Say they get the second pick, Luck doesnt enter, Mallett goes 1st overall, and the Bills arent that high on Locker. However, the class of 2012 and 2013 look promising... You go for the trenches.
I like the DE from Iowa Clayborn. Monster who will almost single-handedly make our defense credible.