Normally, I'd say it would hurt because its a new offense and every game rep the QB can get with the #1s is a big plus. IMO its more important than making your opponent prepare for multiple QBs.
In this instance, though, I dont think this is true as the top 3 WRs arent going to play and Clay may not play as well so getting on the same page with your primary targets isnt going to happen anyway. Given the depleted WR corps, I'd say Rex and Co. are making the right call in splitting the reps and keeping people guessing. I dont see much, if any, harm in it.