Thanks. BBMB refugee.
Nice write up on McD's D http://www.buffalorumblings.com/2017/1/12/14236950/sean-mcdermott-buffalo-bills-head-coach-4-3-defense-all-22
this first image, shows Lo's most likely lineup, where it says Ragland/Preston on the left. You then get Ragland and Preston in the middle.
https://cdn0.vox-cdn.com/thumbor/9kmYMtbT42OqKaYjjayVgVMgN70=/800x0/filters:no_upscale()/cdn0.vox-cdn.com/uploads/chorus_asset/file/7795117/McDermott_4_3_under.jpg
But on the 4-3 over look, he doesn't look like a great fit as he's more off the line, playing zone, maybe blitzing up the middle. Really depends how much McD plans to blitz.
Key question is, who are the 2 LBs in the nickel? Hard to see Lo staying on the field, unless its to sub for Hughes. Ragland and Preston don't give me tons of confidence as our nickel LBs.