In terms of broad trends, looks like the RB position isn't going to be plug n play anymore. We might see more of Breida, if holes are only going to flash open, we need speed. Long term, we need speed and power rather than elusiveness. Get a big back, get him going down hill, and make nickel and dime looks pay a price.
Also, ya know, some decent guards would be nice, along with a firm commitment to an identity in the run game, and an OL coach who can execute it.