LA and SD are both bad sports towns. The chargers moving would be the least painful, after jacksonville. While I'd rather everyone just remain at their current locations, it wouldn't be a big deal for the chargers to move. While there would be an initial outcry from the sd fans, I doubt half of SD's citizens would notice/care, and the chargers would ultimately retain their fans even in LA.
Lived out here in southern california for almost 20 years. Just to reiterate I'd prefer all 32 teams to stay put.