I have to agree with Kelly here. Near Chippewa is where you want to be. Either the Hampton on Chippewa or the Hyatt down Main St.
There used to be a Radisson on Main and Chippewa which I think might now be a Comfort Suites.
If you want to go on the cheap, there is the Buffalo Hostel on Main just 1/2 a block from Chippewa.
Additionally, if staying near Chippewa, I'd recommend hitting up Hemmingway's on Pearl St for wings. They're my favorite place in Buffalo for wings. I always stop there for wings after the dozen or so Sabres games I go to a year.
Which reminds me, the NHL is back in action. You might luck out and be able to catch a Sabres game that weekend also.