I think most teams utilize the run (especially 1st down runs) way too often on their own side of the field when the most important thing should be third-down avoidance. 3rd-and-2 from your own 30-yard line is a "favorable" position to be in, but you're a stuffed run or a batted down pass away from punting. There's almost zero third-down situations in your own territory that I would desire, and if you have multiple 3rd-and-shorts in your own territory on a single drive, the odds of multiple conversions is less than 50-50. Yet most coaches live for such opportunities.
Once you cross the 50, the run game - especially first-down runs - should become far more prominent. You now have four downs to work with instead of 3. No modern team with a good offense like Buffalo is going to punt on 4th-and-3 from the opponent 41 these days.