This concerns me too, but only if they marry themselves to the pick. Conventional wisdom says if you take a 1st rd QB you don't take one the following year, but recent history shows us this is flawed thinking. After EJ's rookie year he should have been viewed no differently from a 3rd rd pick who performed equally. Instead they fell into the sunk cost fallacy. If the Bills are willing to defy the norm if logic dictates I'd be happy to risk #10 on a QB.
That said, I wouldn't risk it on Watson. I find Cahomes and Trubisky intriguing enough to roll the dice. But given Watson's arm strength and style of play he's just too big a ? to take that early.