After disliking Rochester while I was in my 20s, it really dawned on my how damn nice rochester is once I matured. I'm in my 30s now.
If you judge a city by its bars, you may be overlooking other things. Anyone who doesn't like Rochester because the bars are only open until 2:00 is taking a narrow view of things. There are LOTS of things to do in Rochester, and I really love the city. I work with two people my age who decided to move here to buy a house and raise a family. Yes, in WNY you can actually afford to own a house.
The schools here are phenominal. Brighton, Pittsford and Irondequoit all rank in the top 30 in the entire US. The colleges are wonderful. The close proximity to the finger lakes is awesome. The golf (I'm an addict), both public and private, is some of the best in the north east, not to mention that it's affordable here.
Culturally, Rochester is quite good. The philharmonic is one of the best, and the Eastman School of Music is top 5 in the world. There are good plays if you're into that, and there are good festivals as well. There are very good places to eat, too.
If all you want to do is drink and raise hell, live somewhere else. If you want to drink and raise hell and do other stuff as well, Rochester is a good choice.