The Bills have infrequently had their A game this year. They are due. If they bring their A game, they win.
Belichick has done a great job with the Pats this year, maybe his best coaching ever given his losing record without Brady. But watching the game carefully, the Pats are highly choreographed. Jones arm strength is average at best, and on the rare throws over 10 yards, he typically hits only when his man is wide open. Pats have not been thrown off their choreography in this 6 game winning streak. An early punch in the mouth and making them improvise will be the key.