As someone else said, the Bills tend to have at least one shocker under McDermott per season - 54-24 at the Chargers, 47-3 at the Ravens/41-9 v the Bears, 31-13 v the Eagles, 42-16 at the Titans, 41-15 v the Colts, 27-10 v the Bengals.
I suppose we did lose 21-0 at the Panthers is our last pre season game in 2022 though, from memory, not even many of the seconds played in that one. Otherwise, never had a shocker in pre-season under him up to now. Maybe it's a good omen? Getting it out of the way.