The first key is the Bill's ability to tackle and force New England into 3rd and Longs. If New England is able to control time of possession and effectively run the ball, dink and dunk, and keep Allen on the bench, the Bills have an uphill battle.
The second key is to be effective in the Red Zone. If the Bills can get up on top quickly and neutralize the Pats running game, the Bills should have the advantage.
Lastly, the Bills need a balanced attack.