Short answer: based on what he did with Kaepernick, yes.
Longer answer: Assuming that EJ or TT win the starting job, I really see us in good position to run a lot of Pistol. That formation base set runs as such:
-3 WR or 2 WR & 1 TE (Sammy, Woods, Harvin and Clay)
-Feature RB (Shady primarily, but spelled by presumably Freddy, Dixon and Karlos)
-A backfield HB, who can be used as a blocker and backfield receiver option (Clay, Felton and probably Freddy)
He probably has something for Cassel, but that would give a lot of combinations with read option, lead blocker running, jet sweeps from Harvin, screens to Shady and Clay, putting Clay in motion as a 4th recover and breaking out in 5 wide to spice things up.